Molecular Recognition in Biological Systems and Bioinformatics

Synaptic physiology; slice physiology; calcium imaging.

The Xu-Friedman lab studies the mechanisms and functions of synaptic plasticity, focusing on auditory nerve synapses in the cochlear nucleus as a model system. The lab investigates both activity- and neuromodulator-dependent plasticities, using electrophysiology and calcium imaging in brain slices. In addition, the functional effects of plasticity are being studied in mice by assessing their ability to localize and analyze sounds.

• Slice physiology rig
• Calcium imaging
• These are not public domain instruments, but collaborations can be arranged.

• Wavemetrics Igor
• In-house data acquisition software for electrophysiology: mafPC

• Mouse
• Gerbil

Ionotropic and metabotropic receptors

• Hearing
• Deafness

• Electrophysiology
• Slice physiology
• Calcium imaging

• Ear
• Brain

View at:
http://www.biology.buffalo.edu/dept/faculty/xu_friedman/xu_friedman.html
http://www.jneurosci.org/cgi/content/abstract/20/12/4414
http://www.biophysj.org/cgi/content/abstract/76/4/2029