Molecular Recognition in Biological Systems and Bioinformatics

Hyperoxia; neonatal lung injury and repair; growth factors.

The Ryan laboratory explores pathogenesis and prevention of bronchopulmonary dysplasia with a focus on the role of growth factors in hyperoxia-induced neonatal lung fibrosis.

Keratinocyte growth factor, transforming growth factor alpha, proinflammatory cytokines, chemokines, natriuretic peptides

Bronchopulmonary dysplasia, prematurity, lung development

Hyperoxia exposure, type II cell isolation, RPA, Northern hydbridization, Western blotting, anti-oxidant enzyme assays, ELISA

Bronchopulmonary dysplasia

Neonatal lung

D'Angelis CA, Holm BA, Lakshminrusimha S, Nickerson PA, Swartz DD, Sokolowski J, Nielsen L, Ryan RM. Ontogeny of atrial natriuretic peptide and its receptor in the lung: effects on perinatal surfactant release. Ped Research 2008, in press.

Bliss JM, Basavegowda KP, Watson WJ, Sheikh AU, Ryan RM. Vertical and horizontal transmission of Candida albicans in VLBW infants using DNA fingerprinting techniques. Pediatic Infectious Disease Journal 2008, in press.

Ryan RM, Ahmed Q, Lakshminrusimha S. Immunobiology of Inflammatory mediators in the immunobiology of bronchopulmonary dysplasia. Clinical Reviews in Allergy and Immunology 2008, in press.

Lakshminrusimha S, Russell JA, Steinhorn RH, Swartz DD, Ryan RM, Gugino SF, Wynn KA, Kumar VH, Mathew B, Kirmani K, Morin FC. Pulmonary Hemodynamics in Neonatal Lambs Resuscitated with 21%, 50%, and 100% Oxygen. Pediatr Res 2007; 62(3):313-318.

DiGeronimo RJ, Mustafa SB, Ryan RM, Sternberg Z, Ashton DJ, Seidner SR. Mechanical ventilation downregulates surfactant protein A and keratinocyte growth factor expression in premature rabbits. Ped Research 2007; 62(3):277-282