Department of Microbiology and ImmunologyProfessor of Microbiology and Immunology, and Oral Biology
University at Buffalo
111 Biomedical Research Building
Buffalo, NY 14214
University at Buffalo
111 Biomedical Research Building
Buffalo, NY 14214
PH: (716) 829-2790
Web: http://www.smbs.buffalo.edu/wcmpi/facult...
E: russellm@buffalo.edu
Laboratory108-110 Biomedical Research Building
PH: (716) 829-2748
Affiliations
Witebsky Center for Microbial Pathogenesis and ImmunologyMember
Department of Oral BiologyProfessor (joint appointment)
Research
Research Interests
Mucosal immunology; immune response; vaccines; adjuvants; oral microbiology.
Summary of Research
- Novel adjuvants and approaches for developing mucosal vaccines
- Vaccine constructs for prevention of dental caries
- Vaccine constructs for prevention of gonorrhea
- New concepts of the immune response to Neisseria gonorrhoeae
Specialized Instrumentation
96-well microplate reader (variable wavelength, computerized)
Organisms Studied
- Human
- Mouse
- Streptococcus mutans
- Neisseria gonorrhoeae
Genes/Proteins Studied
- Immunoglobulins, especially IgA
- Bacterial surface protein antigens especially S. mutans AgI/II
- Gram-negative heat-labile enterotoxins especially cholera and related toxins as immunomodulating agents
Human Health Connections
- Dental caries
- Gonorrhea
- Vaccine development
Commonly Employed Techniques
- Mucosal immunization and sample collection
- Lymphocyte isolation and culture
- Flow cytometry
- Antibody assay
- Immunoglobulin purification
- Fragmentation
- Derivatization
Specialized Reagents Used
- pCTdeltaA1
- a plasmid for the construction of recombinant chimeric immunogens based on antigen coupled to cholera toxin for mucosal administration
Potential Disease Relatedness
- Dental caries
- Periodontal disease
- Gonorrhea
- Other STIs
Organs Studied
- Oral cavity
- Genital tract