Molecular Recognition in Biological Systems and Bioinformatics

Protein biochemistry; structure-based drug design; bioorganic chemistry.

Bioorthogonal chemistry has emerged as a powerful chemical tool to probe protein structure, function, and activity both in vitro and in living systems. The central goal of our research is to develop a toolbox of photoinducible bioorthogonal reactions, and apply them to i) establish a novel modality of protein photoregulation (photo induced chemical posttranslational modification) in living systems, and ii) discover bioactive small-molecule ligands through target-accelerated in situ synthesis.

• Human
• Mouse
• Rat

• N-Ras
• STAT-1
• Ubiquitination enzymes

Cancer

• Chemical synthesis
• Cell culture
• Cell imaging
• Mass spectrometry

293T, HeLa, PC12

http://www.chem.buffalo.edu/lin_publications.php