Roswell Park Cancer Institute
Elm St. at Carlton St.
Buffalo, NY 14263
PH: (716) 845-3277
Web: http://www.roswellpark.org/Research/Rese...
E: rosemary.elliott@roswellpark.org
Elm St. at Carlton St.
Buffalo, NY 14263
PH: (716) 845-3559
Research
Mouse genetics; cancer susceptibility; colon cancer.
Identification of genes in the mouse, associated with colon cancer susceptibility. Construction of congenic strains carrying short genetic regions from a susceptible strain into a resistant strain, and testing of candidate genes within this short region.
Mouse
Genes involved in colon cancer susceptibility
Identification and testing of cancer susceptibility genes in human tumors.
PCR, tissue culture, apoptosis comparisons, rate of incorporation of nucleotides into DNA.
Human HT29 adenocarcinoma cells, and derivatives we make by introducing sh sequences
Colon
RF, Hohman C, Marshall DJ, Frick TJ, Schlack S, Broda M, Jacoby Smutko J, Elliott RW. Genetic analysis of colon cancer susceptibility in mice. Genomics 22:381-387, 1994.
Lipkin SM, Wang V, Jacoby R, Banerjee-Basu S, Baxevanis AD, Lynch HT, Elliott RW, Collins FS. MLH3: A DNA mismatch repair gene associated with mammalian microsatellite instability. Nat. Genet. 24: 27-35, 2000.