Molecular Recognition in Biological Systems and Bioinformatics

Regulation of gene expression and protein biochemistry in particular relative to ATP synthase and RNA processing.

The primary focus of my research is on the parasitic protozoan, Trypanosoma brucei, the causative agent for African sleeping sickness. These parasites have been difficult to target with vaccines due to the presence of variable surface glycoproteins which facilitate evasion of the host immune surveillance system. Many of the current chemotherapeutic agents are quite toxic and alternative approaches are needed. I am interested in the developmentally regulated processes that are required for successful transmission of the organism from one host to another [e.g. insect to human]. By understanding these processes, we may also be able to prevent transmission and the completion of the life cycle of the parasite. Critical enzyme complexes, such as the mitochondrial ATP synthase, or key processes, such as ribosomal biogenesis, are excellent targets for such transmission blocks.

• Trypanosoma brucei
• Trypanosoma cruzi

• Mitochondrial ATP synthase
• RNA binding proteins p34
• p37
• PABP

Parasite pathogenesis

Gene targeting by RNA interference and knockouts

• Trypanosoma brucei PC 667
• Procyclic and bloodstream 29-13, 427

View at: http://www.smbs.buffalo.edu/wcmpi/Faculty/williams.html