Molecular Recognition in Biological Systems and Bioinformatics

RNA folding and targeting.

Our group is developing a chemical code for targeting RNA with small molecules. We will use this code to rationally design small molecules targeting RNA. Currently, we are applying our code towards targeting inherited breast cancer and microRNAs that play important roles in cancer.

Antibiotic resistance genes and triplet repeat disorders.

Treatment of bacterial infections and genetic disease.

Chemical and carbohydrate microarrays; organic synthesis; RNA structure prediction and experimental validation of RNA structure

E. coli JM109 strains that harbor various aminoglycoside antibiotic resistance genes.

Solid-phase chemical synthesis and combinatorial synthesis library construction. Use chemical microarrays for library screening.

Genetic diseases including muscular dystrophy and other triplet repeat disorders.

http://pubs.acs.org/cgi-bin/abstract.cgi/acbcct/2007/2/i11/abs/cb700174r.html

http://pubs.acs.org/cgi-bin/abstract.cgi/bichaw/2007/46/i40/abs/bi701071h.html

http://www.rnajournal.org/cgi/reprint/rna.576908v1

http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15123812