Department of Physics/Dept. of Biophysics and PhysiologyAssistant Professor
University at Buffalo
229 Fronczak Hall
Buffalo, NY 14260
University at Buffalo
229 Fronczak Hall
Buffalo, NY 14260
PH: (716) 645-2017, ext. 139
Web: http://www.acsu.buffalo.edu/~apralle/
E: apralle@buffalo.edu
LaboratoryUniversity at Buffalo
150 Fronczak Hall
Buffalo, NY 14260
150 Fronczak Hall
Buffalo, NY 14260
PH: (716) 645-5000, ext. 123
Research
Research Interests
Protein structure and function; membrane protein dynamics; voltage-sensitive ion channels.
Summary of Research
We are developing single molecule methods to study the mechanics and structure-function relationships of membrane proteins using fluorescence and laser trap based thermal-noise imaging. For this work we use various nanodot structures as markers and handles. In one particular study, we currently explore ways to use magnetic nanoparticles to trigger ion-channels and excitable cells.
Specialized Instrumentation
Laser trap, single molecule microscopy, high frequency magnetic fields.